Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro.

@article{Sango2003PhosphacanAN,
  title={Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro.},
  author={Kazunori Sango and Atsuhiko Oohira and Kyoko Ajiki and Akiko Tokashiki and Masao Horie and Hitoshi Kawano},
  journal={Experimental neurology},
  year={2003},
  volume={182 1},
  pages={1-11}
}
Phosphacan (PC) and neurocan (NC) are major chondroitin sulfate proteoglycans (CS-PGs) in nervous tissue and are involved in the modulation of cell adhesion and neurite outgrowth during neural development and regeneration. In the present study, we examined the effects of PC and NC on the attachment and neurite extension of adult rat dorsal root ganglion (DRG) neurons in vitro. Treatment with PC and NC on poly-L-lysine (PL) significantly impaired both neuronal attachment and neurite extension in… CONTINUE READING
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Chondroitin sulfate proteoglycan in the rat brain: candidates for axon barriers of sensory neurons and the possible modulation by laminin of their actions

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