Phorbol esters inhibit smooth muscle contractions through activation of Na(+)-K(+)-ATPase.

@article{Sasaguri1990PhorbolEI,
  title={Phorbol esters inhibit smooth muscle contractions through activation of Na(+)-K(+)-ATPase.},
  author={Toshiyuki Sasaguri and Stephanie Watson},
  journal={British journal of pharmacology},
  year={1990},
  volume={99 2},
  pages={237-42}
}
1. The role of protein kinase C (PKC) in agonist-induced contractions of guinea-pig ileum longitudinal smooth muscle has been investigated. 2. The phorbol esters, phorbol 12,13-dibutyrate (PDBu), phorbol 12,13-diacetate (PDA) and phorbol 12-myristate 13-acetate (PMA), relaxed tissues precontracted by submaximal concentrations of carbachol, histamine or substance P. 3. This inhibitory action of the phorbol esters was reversed following the application of ouabain, a specific inhibitor of Na(+)-K… CONTINUE READING

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