Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide.

@article{Hortelano1992PhorbolEI,
  title={Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. Antagonism with the induction elicited by lipopolysaccharide.},
  author={Sonsoles Hortelano and Ana Mar{\'i}a Genaro and Lisardo Bosc{\'a}},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 35},
  pages={24937-40}
}
The incubation of primary cultures of rat hepatocytes with lipopolysaccharide (LPS) or biologically active phorbol esters promotes the release of nitric oxide to the incubation medium. This process is the result of the induction of the Ca(2+)-and calmodulin-independent form of nitric oxide synthase. Both the release of nitric oxide to the incubation medium… CONTINUE READING