Phorbol esters induce neurotransmitter release in cholinergic synaptosomes from Torpedo electric organ.

@article{Guitart1990PhorbolEI,
  title={Phorbol esters induce neurotransmitter release in cholinergic synaptosomes from Torpedo electric organ.},
  author={Xavier Vidal Guitart and Jordi Marsal and Carles Solsona},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 2},
  pages={468-72}
}
The effect of phorbol esters and so the involvement of Ca2+/phospholipid-dependent protein kinase (protein kinase C;PKC) in the release of acetylcholine (ACh) was studied using Torpedo electric organ synaptosomes. 12-O-Tetradecanoylphorbol 13-acetate (TPA), a known activator of PKC, induced neurotransmitter release in a concentration-dependent manner and increased the potassium-evoked release of ACh. The effect of TPA was shown to be independent of the extrasynaptosomal calcium concentration… CONTINUE READING