Phorbol esters affect cyclic nucleotide-mediated responses in cultured chick lens annular pad cells.


Cultured chick lens annular pad cells were treated with a lipid soluble cAMP analog, the phorbol ester TPA or a combination of the two compounds in order to assess their effects on mitotic activity, cell spreading and the accumulation of differentiation marker proteins. Both 8b-cAMP and TPA were individually able to inhibit mitotic activity in cells… (More)