Phorbol ester stimulation of phosphatidylcholine synthesis in four cultured neural cell lines: Correlations with expression of protein kinase C isoforms

@article{Sproull1995PhorbolES,
  title={Phorbol ester stimulation of phosphatidylcholine synthesis in four cultured neural cell lines: Correlations with expression of protein kinase C isoforms},
  author={Scott A. Sproull and Sherry C. Morash and David M. Byers and Frederick B. St. C. Palmer and Dr. Harold W. Cook},
  journal={Neurochemical Research},
  year={1995},
  volume={20},
  pages={1397-1407}
}
Phosphatidylcholine (PtdCho) can provide lipid second messengers involved in signal transduction pathways. As a measure of phospholipid turnover in response to extracellular stimulation, we investigated differential enhancement of [3H]choline incorporation into PtdCho by phorbol esters. In C6 rat glioma and SK-N-SH human neuroblastoma cells, [3H]PtdCho synthesis was 2–4 fold stimulated by β-12-O-tetradecanoylphorbol-13-acetate (β-TPA) when [3H]choline was incubated simultaneously with, or 15… CONTINUE READING
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