Phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis

@article{Shanker1991PhorbolER,
  title={Phorbol ester receptors in cerebral cortex of cats with GM1 gangliosidosis},
  author={Gouri Shanker and Henry J. Baker},
  journal={Neurochemical Research},
  year={1991},
  volume={16},
  pages={11-16}
}
The pathogenesis of neuronal dysfunction in the gangliosidoses is poorly understood. Studies of the feline gangliosidoses and in vitro experiments implicate ganglioside inhibition of protein kinase C (PKC) in the pathogenesis of these neurological diseases. Therefore, in the present study, the binding of [3H]phorbol-12, 13 dibutyrate was measured to… CONTINUE READING