Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event

  title={Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event},
  author={Y N Danilov and Rudolph L Juliano},
  journal={The Journal of Cell Biology},
  pages={1925 - 1933}
Chinese hamster ovary (CHO) suspension culture cells adhere readily to substrata coated with extracellular matrix proteins such as fibronectin, vitronectin, or laminin. In the case of fibronectin, it is known that adhesion is mediated by an integrin-type, cell surface fibronectin receptor (FnR). We demonstrate here that treatment of CHO cells with submicromolar concentrations of phorbol ester produces a remarkable increase in the ability of these cells to adhere to fibronectin. Both the rate of… CONTINUE READING
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12 - O - tetradecanoylphorbol - 13 - acetate disrupts actin filaments and focal contacts and enhances binding of fibronectin coated latex beads to 3 T 3 - LI ceils

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