Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements.

@article{Harris1998PhorbolET,
  title={Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements.},
  author={Violaine K Harris and Emmanuelle D.E. Liaudet-Coopman and Bryan J. Boyle and Anton Wellstein and Anna Tate Riegel},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 30},
  pages={19130-9}
}
Earlier studies from our laboratory showed that a secreted binding protein for fibroblast growth factors (FGF-BP) is expressed at high levels in squamous cell carcinoma (SCC) cell lines. Overexpression studies or conversely reduced expression of FGF-BP by ribozyme targeting have elucidated a direct role of this protein in angiogenesis during tumor development. We have also observed a significant up-regulation of FGF-BP during TPA (12-O-tetradecanoylphorbol-13-acetate) promotion of skin cancer… CONTINUE READING

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