Phorbol ester-induced disruption of the CD4-Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated protein kinase C isoforms.

@article{Parolini1999PhorbolED,
  title={Phorbol ester-induced disruption of the CD4-Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated protein kinase C isoforms.},
  author={Isabella Parolini and Stefania Topa and Maurizio Sorice and Andrea Pace and Pier Giuseppe Ceddia and Elisabetta Montesoro and Antonio Pavan and Michael p. Lisanti and Cesare Peschle and Massimo Sargiacomo},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 20},
  pages={
          14176-87
        }
}
Recent studies have highlighted the existence of discrete microdomains at the cell surface that are distinct from caveolae. The function of these microdomains remains unknown. However, recent evidence suggests that they may participate in a subset of transmembrane signaling events. In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enriched in signaling molecules, such as cell surface receptors (CD4 and CD55… CONTINUE READING

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