Phorbol ester differentially regulates oxytocin receptor binding activity in hypothalamic cultured neurons and astrocytes.

@article{Strosser2001PhorbolED,
  title={Phorbol ester differentially regulates oxytocin receptor binding activity in hypothalamic cultured neurons and astrocytes.},
  author={M. T. Strosser and Marilyn Evrard and Christophe Breton and Dominique Guenot-Di Scala},
  journal={Peptides},
  year={2001},
  volume={22 4},
  pages={677-83}
}
Hypothalamic cultured neurons and astrocytes were used to investigate the cellular mechanisms underlying the oxytocin receptor-mediated downregulation through a possible involvement of protein kinase C (PKC). For this purpose, the effects of PKC activators, inhibitor and of OT on OT receptor binding activity were compared in both cultures. In neurons, phorbol-myristate-acetate (PMA), a potent PKC activator, increased the binding of an OT receptor antagonist whereas in astrocytes, a decrease was… CONTINUE READING