Phorbol ester and okadaic acid-resistant cells: the crossroads of signal transduction and drug resistance.

@article{Saijo1995PhorbolEA,
  title={Phorbol ester and okadaic acid-resistant cells: the crossroads of signal transduction and drug resistance.},
  author={Nagahiro George Saijo and Kazuto Nishio and Yutaka Takeda and Hitoshi Arioka and Tomoyuki Ishida and Tatsuya Nomoto and Kazuya Fukuoka and Hirokazu Kurokawa and Hisaoh Fukumoto},
  journal={The American journal of medicine},
  year={1995},
  volume={99 6A},
  pages={35S-39S}
}
Many factors are involved in the development of drug resistance for anticancer drugs. The drugs should pharmacokinetically attain the appropriate concentration. They should be metabolized to the active forms. Tumor cells should have sensitivity to them. Several molecular and biochemical mechanisms that may explain cellular drug resistance have been… CONTINUE READING