Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

@article{Signoret1997PhorbolEA,
  title={Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4 },
  author={Natalie Signoret and Joanne Oldridge and Annegret Pelchen-Matthews and Per Johan Klasse and T. -N. Tran and Lawrence F Brass and Mette Marie Rosenkilde and Thue W. Schwartz and William Holmes and Walt Dallas and Michael A. Luther and Timothy N. C. Wells and James A Hoxie and Mark Marsh},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={139},
  pages={651 - 664}
}
The chemokine receptor CXCR4 is required, together with CD4, for entry by some isolates of HIV-1, particularly those that emerge late in infection. The use of CXCR4 by these viruses likely has profound effects on viral host range and correlates with the evolution of immunodeficiency. Stromal cell-derived factor-1 (SDF-1), the ligand for CXCR4, can inhibit infection by CXCR4-dependent viruses. To understand the mechanism of this inhibition, we used a monoclonal antibody that is specific for… CONTINUE READING
160 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 160 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

CD4-induced changes in gp120/gp41 confomation and its potential relationship to fusion

  • H. Ellens, C. Larsen
  • In Viral Fusion Mechanisms. J. Bentz, editor. CRC…
  • 1993
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…