Phorbol Esters: Structure, Biological Activity, and Toxicity in Animals

@article{Goel2007PhorbolES,
  title={Phorbol Esters: Structure, Biological Activity, and Toxicity in Animals},
  author={Gunjan Goel and Harinder P. S. Makkar and George Francis and Klaus Becker},
  journal={International Journal of Toxicology},
  year={2007},
  volume={26},
  pages={279 - 288}
}
Phorbol esters are the tetracyclic diterpenoids generally known for their tumor promoting activity. The phorbol esters mimic the action of diacyl glycerol (DAG), activator of protein kinase C, which regulates different signal transduction pathways and other cellular metabolic activities. They occur naturally in many plants of the family Euphorbiacaeae and Thymelaeaceae. The biological activities of the phorbol esters are highly structure specific. The phorbol esters, even at very low… Expand
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TLDR
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TLDR
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Occular and dermal toxicity of Jatropha curcas phorbol esters.
TLDR
Conclusively, topical applications of Jatropha PEs are toxic towards RHE and HCE models, which represents dermal and occular toxicity respectively. Expand
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Phorbol esters present in Jatropha curcas oil are toxic when consumed and are co-carcinogens. These could be a potential constraint in the widespread acceptance of Jatropha oil as a source ofExpand
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Biodiesel fuel (BDF) is an important alternative fuel because of the carbon neutral nature of biomass and the exhaustion of fossil fuel resources. Jatropha curcas oil (JCO) produced from J. curcasExpand
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