Phorbol Ester-induced Differentiation of Human T-Lymphoblastic Cell Line HPB-ALL 1

Abstract

12-O-Tetradecanoylphorbol-13-acetate (TPA), a potent tu mor promoter, induced phenotypic differentiation in the human thymic acute lymphocytic leukemia cell line, HPB-ALL. Within 30 min of seeding in the presence of TPA, the cells formed a smooth round shape. After a 7-day exposure to TPA, most of the cells became smaller and reminiscent of large or… (More)

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