Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway.

Abstract

In secretory epithelial cells, the basolateral Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) plays a major role in salt and fluid secretion. Our laboratory has identified NKCC1 surface expression as an important regulatory mechanism for Cl(-) secretion in the colonic crypt cell line T84, a process also present in native human colonic crypts. We previously showed… (More)
DOI: 10.1152/ajpcell.00118.2009

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@article{Mykoniatis2010Phorbol11, title={Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway.}, author={Andreas Mykoniatis and Le Shen and Mary Fedor-Chaiken and Jun Tang and Xu Tang and Roger T. Worrell and Eric Delpire and Jerrold R Turner and Karl S Matlin and Patrice G. Bouyer and Jeffrey B. Matthews}, journal={American journal of physiology. Cell physiology}, year={2010}, volume={298 1}, pages={C85-97} }