Phorbol-12,13-diester 12-ester hydrolase may prevent tumour promotion by phorbol diesters in skin

@article{Shoyab1982Phorbol1213diester1H,
  title={Phorbol-12,13-diester 12-ester hydrolase may prevent tumour promotion by phorbol diesters in skin},
  author={Mohammed Shoyab and Thomas C. Warren and George J. Todaro},
  journal={Nature},
  year={1982},
  volume={295},
  pages={152-154}
}
Tumour promoters are not themselves carcinogenic but can induce tumours in mice treated previously with an otherwise insufficient dose of certain chemical carcinogens1–6. One of the most potent tumour-promoting agents is 12-O-tetradecanoyl-phorbol-13-acetate (TPA), initially isolated from croton oil7. The effects of tumour promoters are species specific8; croton oil, of which TPA is the most active component, does not act as a tumour promoter in rat, rabbit, guinea pig or hamster skin in… CONTINUE READING

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