Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.

@article{Halayko2004Phophatidylinositol3KT,
  title={Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.},
  author={Andrew J Halayko and Sreedharan Kartha and Gerald L. Stelmack and John McConville and John Tam and Blanca Camoretti-Mercado and Sean M Forsythe and Marc B Hershenson and Julian Solway},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={31 3},
  pages={266-75}
}
Increased airway smooth muscle in airway remodeling results from myocyte proliferation and hypertrophy. Skeletal and vascular smooth muscle hypertrophy is induced by phosphatidylinositide-3 kinase (PI(3) kinase) via mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K). We tested the hypothesis that this pathway regulates contractile protein accumulation in cultured canine airway myocytes acquiring an elongated contractile phenotype in serum-free culture. In vitro assays revealed a… CONTINUE READING

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