PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosis.

@article{Shi2010PhoY2BN,
  title={PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosis.},
  author={Wanliang Shi and Ying Zhang},
  journal={The Journal of antimicrobial chemotherapy},
  year={2010},
  volume={65 6},
  pages={1237-42}
}
OBJECTIVES Mycobacterial persistence is thought to be the underlying cause of the current lengthy tuberculosis therapy and latent infection. Despite some recent progress, the mechanisms of bacterial persistence are poorly understood. We have recently identified a new persister gene phoU from Escherichia coli and have shown that the phoU mutant has a defect in persisters. The objective of this study is to evaluate the role of two phoU homologues phoY1 and phoY2 from Mycobacterium tuberculosis in… CONTINUE READING

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