Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats

@article{Malatiali2008PhlorizinPG,
  title={Phlorizin Prevents Glomerular Hyperfiltration but  not Hypertrophy in Diabetic Rats},
  author={Slava A. Malatiali and Issam M. Francis and M Barac-nieto},
  journal={Experimental Diabetes Research},
  year={2008},
  volume={2008},
  pages={387 - 393}
}
The relationships of renal and glomerular hypertrophies to development of hyperfiltration and proteinuria early in streptozotocin-induced diabetes were explored. Control, diabetic, phlorizin-treated controls, and diabetic male Fischer rats were used. Phlorizin (an Na+-glucose cotransport inhibitor) was given at a dose sufficient to normalize blood glucose. Inulin clearance (C(inulin)) and protein excretion rate (PER) were measured. For morphometry, kidney sections were stained with periodic… CONTINUE READING