Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl(-) channels.

@article{Fan2001PhloretinDI,
  title={Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl(-) channels.},
  author={Hua-hua Fan and Shigeru Morishima and Hiroyuki Kida and Yasunobu Okada},
  journal={British journal of pharmacology},
  year={2001},
  volume={133 7},
  pages={1096-106}
}
Some phenol derivatives are known to block volume-sensitive Cl(-) channels. However, effects on the channel of the bisphenol phloretin, which is a known blocker of glucose uniport and anion antiport, have not been examined. In the present study, we investigated the effects of phloretin on volume-sensitive Cl(-) channels in comparison with cyclic AMP… CONTINUE READING