Phlebotomus orientalis Sand Flies from Two Geographically Distant Ethiopian Localities: Biology, Genetic Analyses and Susceptibility to Leishmania donovani

@article{Seblov2013PhlebotomusOS,
  title={Phlebotomus orientalis Sand Flies from Two Geographically Distant Ethiopian Localities: Biology, Genetic Analyses and Susceptibility to Leishmania donovani},
  author={V. Seblov{\'a} and V. Volfov{\'a} and V. Dvorak and Kateřina Pru{\vz}inov{\'a} and J. Vot{\'y}pka and Aysheshm Kassahun and T. Gebre-Michael and A. Hailu and A. Warburg and P. Volf},
  journal={PLoS Neglected Tropical Diseases},
  year={2013},
  volume={7}
}
Background Phlebotomus orientalis Parrot (Diptera: Psychodidae) is the main vector of visceral leishmaniasis (VL) caused by Leishmania donovani in East Africa. Here we report on life cycle parameters and susceptibility to L. donovani of two P. orientalis colonies originating from different sites in Ethiopia: a non-endemic site in the lowlands - Melka Werer (MW), and an endemic focus of human VL in the highlands - Addis Zemen (AZ). Methodology/Principal Findings Marked differences in life-cycle… Expand
Species composition of phlebotomine sand flies and bionomics of Phlebotomus orientalis (Diptera: Psychodidae) in an endemic focus of visceral leishmaniasis in Tahtay Adiyabo district, Northern Ethiopia
TLDR
P. orientalis was found to be the most abundant Phlebotomus species, showing marked seasonal abundance that mainly peaks during the dry season (March to April) and likewise, the people in the area usually sleep in compounds during these months that potentially expose them to a high risk of peri-domestic VL transmission. Expand
Some aspects of entomological determinants of Phlebotomus orientalis in highland and lowland visceral leishmaniasis foci in northwestern Ethiopia
TLDR
The present study showed parity difference between the two populations of P. orientalis and that both populations have strong zoophilic behavior and vector control should be a component of a strategy to manage visceral leishmaniasis in both study areas. Expand
Genetic Variability of the Populations of Phlebotomus papatasi, the Main Vector of Leishmania major, in Al-Madinah Al-Munawarah, Saudi Arabia
TLDR
The phylogenetic and genetic distance analyses generated from the RAPD-PCR profiles showed close relationships between Almondasa and Almaliliah populations, while the largest genetic distance was detected between the populations of Almondaa and Agool. Expand
Comparative Analysis of Salivary Gland Transcriptomes of Phlebotomus orientalis Sand Flies from Endemic and Non-endemic Foci of Visceral Leishmaniasis
TLDR
It is demonstrated that the different epidemiology of VL in these Ethiopian foci cannot be attributed to the salivary gland composition, and there is no significant difference between the transcriptomes, proteomes or enzymatic properties of theSalivary components of Addis Zemen and Melka Werer P. orientalis colonies. Expand
The Development of Leishmania tropica in Sand Flies (Diptera: Psychodidae): A Comparison of Colonies Differing in Geographical Origin and a Gregarine Coinfection
TLDR
The similar development of Leishmania in both sand fly colonies indicates that the different geographical origin of P. sergenti is not reflected by a different vector competence to L. tropica. Expand
Studies on sand fly fauna and ecological analysis of Phlebotomus orientalis in the highland and lowland foci of kala-azar in northwestern Ethiopia
TLDR
The current study indicated the variation in sand fly fauna between the highland and lowland districts, wherein, P. orientalis was found to be the most abundant Phlebotomus species. Expand
Usos y tendencias de marcadores moleculares en flebotomíneos (Diptera: Psychodidae)
TLDR
Future research using molecular markers in the study of sandflies should be aimed towards: a) the development of genetic barcoding as a complementary tool for morphological identification and b) genome sequencing to increase the understanding of host-parasite interactions. Expand
Genomic analysis of natural intra-specific hybrids among Ethiopian isolates of Leishmania donovani
TLDR
The results demonstrate that recombination is a significant feature of natural populations and contributes to the growing body of data that shows how recombination, and gene flow, shape natural populations of Leishmania. Expand
Transmissibility of Leishmania infantum from maned wolves (Chrysocyon brachyurus) and bush dogs (Speothos venaticus) to Lutzomyia longipalpis.
TLDR
It is demonstrated that maned wolves and bush dogs asymptomatically infected with L. infantum are capable of transmitting Leishmania infantum to the invertebrate host L. longipalpis, although the parasite loads in engorged phlebotomines exposed to these animals were very low. Expand
Xenodiagnosis of Leishmania donovani in BALB/c mice using Phlebotomus orientalis: a new laboratory model
TLDR
The study showed that BALB/c mice harbored parasites in sufficient numbers to promote heavy infections in P. orientalis and thus comprised a suitable laboratory model for xenodiagnoses of L. donovani. Expand
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