Philippine Ayta possess the highest level of Denisovan ancestry in the world

@article{Larena2021PhilippineAP,
  title={Philippine Ayta possess the highest level of Denisovan ancestry in the world},
  author={Maximilian Larena and James McKenna and Federico S{\'a}nchez-Quinto and Carolina Bernhardsson and Carlo Ebeo and Rebecca Reyes and Ophelia Casel and Jin-Yuan Huang and Kim Pullupul Hagada and Dennis Guilay and Jennelyn Reyes and Fatima Pir Allian and Virgilio Mori and Lahaina Sue Azarcon and Alma B. Manera and Celito Terando and Lucio Jamero and Gauden Sireg and Renefe Manginsay-Tremedal and Maria Shiela Labos and Richard Dian Vilar and Acram Latiph and Rodelio Linsahay Saway and Erwin Marte and Pablito Magbanua and Amor Morales and Ismael Java and Rudy Reveche and Becky Barrios and Erlinda Burton and Jesus Christopher Salon and Ma. Junaliah Tuazon Kels and Adrian Albano and Rose Beatrix Cruz-Angeles and Edison Molanida and Lena Graneh{\"a}ll and M{\'a}rio Vicente and Hanna Edlund and Jun Hun Loo and Jean A. Trejaut and Simon Y. W. Ho and Lawrence Reid and Kurt Lambeck and Helena Malmstr{\"o}m and Carina M. Schlebusch and Phillip Endicott and Mattias Jakobsson},
  journal={Current Biology},
  year={2021},
  volume={31},
  pages={4219 - 4230.e10}
}

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References

SHOWING 1-10 OF 105 REFERENCES
Discerning the Origins of the Negritos, First Sundaland People: Deep Divergence and Archaic Admixture
TLDR
Phylogenetic tree analyses show that Negritos are basal to other East and Southeast Asians, and that they diverged from West Eurasians at least 38,000 years ago.
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture.
TLDR
The results corroborate widespread Denisovan ancestry in ISEA populations, but fail to detect any substantial super-archaic admixture signals compatible with the endemic fossil record of ISEA.
Genetic evidence for archaic admixture in Africa
TLDR
DNA sequence data gathered from 61 noncoding autosomal regions in a sample of three sub-Saharan African populations are used to test models of African archaic admixture and suggest that polymorphisms present in extant populations introgressed via relatively recent interbreeding with hominin forms that diverged from the ancestors of modern humans in the Lower-Middle Pleistocene.
Unravelling the Genetic History of Negritos and Indigenous Populations of Southeast Asia
TLDR
The continuum in divergence time from Negritos to Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions.
Archaic human ancestry in East Asia
TLDR
The results suggest admixture between Denisovans or a Denisova-related population and the ancestors of East Asians, and that the history of anatomically modern and archaic humans might be more complex than previously proposed.
Genetic history of an archaic hominin group from Denisova Cave in Siberia
TLDR
A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.
A highcoverage genome sequence from an archaic
  • Denisovan individual
  • 2012
...
...