Philadelphia chromosome-positive acute myeloid leukemia: a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis.

@article{Soupir2007PhiladelphiaCA,
  title={Philadelphia chromosome-positive acute myeloid leukemia: a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis.},
  author={Chad P Soupir and Jo-Anne Vergilio and Paola Dal Cin and Alona Muzikansky and Hagop A Kantarjian and Dan B. Jones and R. P. Hasserjian},
  journal={American journal of clinical pathology},
  year={2007},
  volume={127 4},
  pages={642-50}
}
We performed a multi-institutional retrospective analysis of the morphologic features, immunophenotype, cytogenetics, and BCR-ABL transcript characterization of cases of Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML). We compared these cases with cases of documented chronic myelogenous leukemia in myeloid blast crisis (CML-MBC). Patients with Ph+ AML were less likely to have splenomegaly or peripheral basophilia and had lower bone marrow cellularity and myeloid/erythroid… CONTINUE READING