Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives.

@article{Lee2011PhiladelphiaCA,
  title={Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives.},
  author={Hun J Lee and James Edwin Thompson and Eunice S. Wang and Meir Wetzler},
  journal={Cancer},
  year={2011},
  volume={117 8},
  pages={1583-94}
}
The Philadelphia chromosome (Ph) is the most common cytogenetic abnormality associated with adult acute lymphoblastic leukemia (ALL). Before the advent of tyrosine kinase inhibitors (TKIs), Ph-positive ALL carried a dismal prognosis and was characterized by a poor response to most chemotherapy combinations, short remission durations, and poor survival rates. Outcomes for patients with Ph-positive ALL improved substantially with the introduction of TKIs, and the TKI imatinib induced complete… CONTINUE READING
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Switch pocket inhibitors of the ABL tyrosine kinase: distinct kinome inhibition profiles and in vivo efficacy in mouse models of CML and B-lymphoblastic leukemia induced by BCR-ABL T315I [abstract

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