PhiC31 integrase induces efficient site-specific excision in zebrafish

Abstract

Site-specific recombinases catalyze recombination between specific targeting sites to delete, insert, invert, or exchange DNA with high fidelity. In addition to the widely used Cre and Flp recombinases, the phiC31 integrase system from Streptomyces phage may also be used for these genetic manipulations in eukaryotic cells. Unlike Cre and Flp, phiC31… (More)
DOI: 10.1007/s11248-010-9394-5

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