Pheochromocytoma in multiple endocrine neoplasia type II: an example of the two-hit theory of neoplasia.

Abstract

Six kindreds in which pheochromocytomas were present as manifestations of the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type II were studied. The patients underwent bilateral total adrenalectomy with the finding that the pheochromocytomas were bilateral, multifocal, and associated with distinct medullary hyperplasia and reduction in… (More)

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@article{Cerny1982PheochromocytomaIM, title={Pheochromocytoma in multiple endocrine neoplasia type II: an example of the two-hit theory of neoplasia.}, author={Jan Cerny and Carlayne Jackson and Gary Brian Talpos and Jessica Yott and Min Woo Lee}, journal={Surgery}, year={1982}, volume={92 5}, pages={849-52} }