Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice

@article{Powers2000PheochromocytomaCL,
  title={Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice},
  author={James F. Powers and Marian J. Evinger and Panayiotis Tsokas and Shahinaz Bedri and Joseph Alroy and Mehzad Shahsavari and Arthur S. Tischler},
  journal={Cell and Tissue Research},
  year={2000},
  volume={302},
  pages={309-320}
}
Transplantable tumors and cell lines have been developed from pheochromocytomas arising in mice with a heterozygous knockout mutation of the neurofibromatosis gene, Nf1. Nf1 encodes a ras-GTPase-activating protein, neurofibromin, and mouse pheochromocytoma (MPC) cells in primary cultures typically show extensive spontaneous neuronal differentiation that may result from the loss of the remaining wild-type allele and defective regulation of ras signaling. However, all MPC cell lines express… CONTINUE READING

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