• DOI:10.1038/nrc3648
Corpus ID: 31457232

Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity

@article{Dahia2014PheochromocytomaAP,
  title={Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity},
  author={P. Dahia},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={108-119}
}

P. Dahia

Published 2014

Biology, Medicine

Nature Reviews Cancer

The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest degree of heritability in human neoplasms, enabling genetic alterations to be traced to clinical phenotypes through their transmission in families. Mutations in more than a dozen distinct susceptibility genes have implicated multiple pathways in these tumours, offering insights into kinase downstream signalling interactions and hypoxia regulation, and uncovering links between metabolism, epigenetic remodelling and… CONTINUE READING

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