Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity

  title={Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity},
  author={P. Dahia},
  journal={Nature Reviews Cancer},
  • P. Dahia
  • Published 2014
  • Biology, Medicine
  • Nature Reviews Cancer
  • The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest degree of heritability in human neoplasms, enabling genetic alterations to be traced to clinical phenotypes through their transmission in families. Mutations in more than a dozen distinct susceptibility genes have implicated multiple pathways in these tumours, offering insights into kinase downstream signalling interactions and hypoxia regulation, and uncovering links between metabolism, epigenetic remodelling and… CONTINUE READING
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