Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity

@article{Dahia2014PheochromocytomaAP,
  title={Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity},
  author={P. Dahia},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={108-119}
}
  • P. Dahia
  • Published 2014
  • Biology, Medicine
  • Nature Reviews Cancer
  • The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest degree of heritability in human neoplasms, enabling genetic alterations to be traced to clinical phenotypes through their transmission in families. Mutations in more than a dozen distinct susceptibility genes have implicated multiple pathways in these tumours, offering insights into kinase downstream signalling interactions and hypoxia regulation, and uncovering links between metabolism, epigenetic remodelling and… CONTINUE READING
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    Observational Patient Registry Clinical Trial
    Pheochromocytomas and paragangliomas are neural crest-derived tumors of the nervous system that are often inherited and genetically heterogeneous. Genetic screening is recommended for… Expand
    ConditionsAssociated Conditions, Bone Cancer, Inherited Cancer Syndrome, (+5 more)
    InterventionGenetic
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