Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background.

@article{Fishbein2012PheochromocytomaAP,
  title={Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background.},
  author={Lauren Fishbein and Katherine L Nathanson},
  journal={Cancer genetics},
  year={2012},
  volume={205 1-2},
  pages={1-11}
}
Pheochromocytomas and paragangliomas (PCC/PGL) are tumors derived from the adrenal medulla or extra-adrenal ganglia, respectively. They are rare and often benign tumors that are associated with high morbidity and mortality due to mass effect and high circulating catecholamines. Although most PCCs and PGLs are thought to be sporadic, over one third are associated with 10 known susceptibility genes. Mutations in three genes causing well characterized tumor syndromes are associated with an… CONTINUE READING
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