Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation.

@article{Cuttle2000PhenytoinMB,
  title={Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation.},
  author={Lyle Cuttle and A J Munns and N A Hogg and Justin R Scott and Wayne D. Hooper and Ronald G Dickinson and Elizabeth M J Gillam},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 8},
  pages={945-50}
}
The anticonvulsant phenytoin (5,5-diphenylhydantoin) provokes a skin rash in 5 to 10% of patients, which heralds the start of an idiosyncratic reaction that may result from covalent modification of normal self proteins by reactive drug metabolites. Phenytoin is metabolized by cytochrome P450 (P450) enzymes primarily to 5-(p-hydroxyphenyl-),5-phenylhydantoin (HPPH), which may be further metabolized to a catechol that spontaneously oxidizes to semiquinone and quinone species that covalently… CONTINUE READING

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