Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.

@article{Carl1997PhenytoininducedDO,
  title={Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.},
  author={G. Carl and F. Hudson and B. S. McGuire},
  journal={The Journal of nutrition},
  year={1997},
  volume={127 11},
  pages={
          2231-8
        }
}
  • G. Carl, F. Hudson, B. S. McGuire
  • Published 1997
  • Chemistry, Medicine
  • The Journal of nutrition
  • The anticonvulsant phenytoin causes a decrease in plasma concentrations of folate in epileptic patients. The mechanism underlying this depletion is unknown. To study this mechanism, phenytoin was administered to rats by addition to the diet (3 g phenytoin/kg diet) for up to 8 wk. At selected times during phenytoin administration (0, 3, 7, 10, 14, 28, 42 and 56 d), the composition of the folate pools of intestinal mucosa, liver, bile and brain was determined. The 0-d administration served as the… CONTINUE READING
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