Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.

@article{Carl1997PhenytoininducedDO,
  title={Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.},
  author={G. Carl and F. Hudson and B. S. McGuire},
  journal={The Journal of nutrition},
  year={1997},
  volume={127 11},
  pages={
          2231-8
        }
}
  • G. Carl, F. Hudson, B. S. McGuire
  • Published 1997
  • Chemistry, Medicine
  • The Journal of nutrition
    • The anticonvulsant phenytoin causes a decrease in plasma concentrations of folate in epileptic patients. The mechanism underlying this depletion is unknown. To study this mechanism, phenytoin was administered to rats by addition to the diet (3 g phenytoin/kg diet) for up to 8 wk. At selected times during phenytoin administration (0, 3, 7, 10, 14, 28, 42 and 56 d), the composition of the folate pools of intestinal mucosa, liver, bile and brain was determined. The 0-d administration served as the… CONTINUE READING
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    18 Citations
    Background Citations
    4
    Results Citations
    2
    18 Citations
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    Citation Type

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    Effect of folic acid and vitamin B12 administration on phenytoin induced toxicity in rats
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    Phenytoin-Folate Interactions: How Far is Safe Folate Supplementation in Phenytoin Treated Epileptic Patients?
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    Vitamin b 12 supplementation: effects on some biochemical and haematological indices of rats on phenytoin administration
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    The dynamics of folic acid metabolism in an adult given a small tracer dose of 14C-folic acid.
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    Bisphosphonates in phenytoin-induced bone disorder.
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    Determinants of Plasma Homocysteine
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    Rat liver folate metabolism can provide an independent functioning of associated metabolic pathways
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    Phenytoin ameliorates the memory deficit induced in the young chick by ethanol toxicity in association with thiamine deficiency
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    Developmental Toxicants Potentially Acting via Folate Perturbation
    • 1

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