Phenytoin-induced IgG2 and IgG4 deficiencies in a patient with epilepsy.

@article{Ishizaka1992PhenytoininducedIA,
  title={Phenytoin-induced IgG2 and IgG4 deficiencies in a patient with epilepsy.},
  author={Akitoshi Ishizaka and Mamoru Nakanishi and Etsuo Kasahara and Kayo Mizutani and Yumiko Sakiyama and Shin Matsumoto},
  journal={Acta paediatrica},
  year={1992},
  volume={81 8},
  pages={
          646-8
        }
}
A five-year-old girl with epilepsy and recurrent respiratory infections was investigated for serum IgG subclass concentrations. She was diagnosed as having a combined deficiency of IgG2 and IgG4 with a decreased serum concentration of IgA and IgG3 and was given replacement therapy with i.v. immunoglobulins. Since then, she has been free from respiratory infections. After phenytoin therapy was stopped, IgG subclass deficiency improved. This case describes the further action of phenytoin on the… CONTINUE READING

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