Phenytoin elimination in childhood: effect of concentration-dependent kinetics.


The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations between 10 to 20 mg per liter, the average… (More)


  • Presentations referencing similar topics