Phenytoin dose adjustment in epileptic patients.

  title={Phenytoin dose adjustment in epileptic patients.},
  author={G E Mawer and P. W. Mullen and Mary Rodgers and Arthur J. Robins and Samuel B. Lucas},
  journal={British journal of clinical pharmacology},
  volume={1 2},
1 A preliminary survey showed that many outpatients with partially controlled epilepsy had serum concentrations of phenytoin below the recommended therapeutic range (10-20 μg/ml). A phenytoin tolerance test was devised with the intention of predicting a more adequate daily dose for such a patient. 2 Fifteen patients were each given an oral test dose of 600 mg phenytoin sodium and the serum concentration of phenytoin was measured at intervals over 48 h; the concentration rose during the first 4… CONTINUE READING

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