Phenytoin and plasmapheresis: importance of sampling times and impact of obesity.

Abstract

The effect of plasmapheresis (PP) on total and free phenytoin clearance is reported. An obese patient with the diagnosis of thrombotic thrombocytopenic purpura (TTP) was treated with PP. Twelve episodes of PP, having exchange volumes of 1.5-2.25 times the plasma volume with a mean +/- SD 7.7 +/- 0.8 L of plasma removed, were studied. A significant (p < 0.05… (More)

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@article{Olsen1994PhenytoinAP, title={Phenytoin and plasmapheresis: importance of sampling times and impact of obesity.}, author={Keith M. Olsen and Michael A Marx and Michael S. Monaghan and Elizabeth Barnes and Bruce H Ackerman and Alex A. Pappas}, journal={Therapeutic drug monitoring}, year={1994}, volume={16 6}, pages={624-8} }