Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia.

@article{Iacopino1997PhenytoinAC,
  title={Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia.},
  author={Anthony M. Iacopino and D. L. Doxey and Christopher W Cutler and Salvador Nares and Kari Stoever and J. Fojt and Alexandra Gonzales and Russell Eugene Dill},
  journal={Journal of periodontology},
  year={1997},
  volume={68 1},
  pages={
          73-83
        }
}
Phenytoin (pht) is an anticonvulsant drug commonly used for the prevention of seizures. A common side effect of PHT therapy is gingival hyperplasia, occasionally so severe that it requires surgical intervention. Cyclosporine A (CSA) is a drug widely used for the control of rejection phenomena following solid organ and bone marrow transplantation. A frequent side effect of CSA administration is gingival overgrowth. As yet, the molecular mechanisms of drug-induced gingival hyperplasia are unknown… CONTINUE READING

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