Phenytoin and carbamazepine: potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers.

@article{Schwarz1989PhenytoinAC,
  title={Phenytoin and carbamazepine: potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers.},
  author={J{\"u}rgen R Schwarz and G Grigat},
  journal={Epilepsia},
  year={1989},
  volume={30 3},
  pages={286-94}
}
Voltage clamp experiments were performed in single myelinated nerve fibers of the rat and the effects of phenytoin (PHT) and carbamazepine (CBZ) on the ionic membrane currents were studied. PHT and CBZ are almost selective blockers of Na channels. The main part of this inhibition is a potential-dependent block which can be removed by hyperpolarization. The dose-response curve of PHT was described as a first-order reaction with Kd = 37 microM; 100 microM CBZ was equally as effective 100 microM… CONTINUE READING