Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties

@inproceedings{Colombo2013PhenytoinIT,
  title={Phenytoin Inhibits the Persistent Sodium Current in Neocortical Neurons by Modifying Its Inactivation Properties},
  author={Elisa Silvia Colombo and Silvana Franceschetti and G. Avanzini and Massimo Mantegazza},
  booktitle={PloS one},
  year={2013}
}
The persistent Na⁺ current (I(NaP)) is important for neuronal functions and can play a role in several pathologies, although it is small compared to the transient Na⁺ current (I(NaT)). Notably, I(NaP) is not a real persistent current because it undergoes inactivation with kinetics in the order of tens of seconds, but this property has often been overlooked. Na⁺ channel blockers, drugs used for treating epilepsy and other diseases, can inhibit I(NaP), but the mechanism of this action and the… CONTINUE READING

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