Phenytoin Dosage Individualization–five Methods Compared in the Elderly

  title={Phenytoin Dosage Individualization–five Methods Compared in the Elderly},
  author={Steve A. Hudson and David L. Farquhar and David Thompson and Roselyn G. Smith},
  journal={Journal of clinical pharmacy and therapeutics},
  volume={15 1},
Five methods to predict phenytoin dosage have been compared in nine continuous care elderly patients. For each patient three steady-state plasma concentrations were obtained at three different doses. The data were used to estimate the 'optimum' dose for each patient by direct linear plot. The optimum dose for each patient was predicted from each plasma concentration using five dosage prediction methods based on the Michaelis-Menten equation using: (i) the population mean Vmax, (ii) the… CONTINUE READING


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