Phenytoin‐Folate Interactions: Differing Effects of the Sodium Salt and the Free Acid of Phenytoin

@article{Carl1992PhenytoinFolateID,
  title={Phenytoin‐Folate Interactions: Differing Effects of the Sodium Salt and the Free Acid of Phenytoin},
  author={G. Carl and M. L. Smith},
  journal={Epilepsia},
  year={1992},
  volume={33}
}
Summary: Chronic phenytoin (PHT) treatment has long been associated with folate deficiency. It has been suggested that pH changes in the gut associated with PHT ingestion may be responsible for decreased folate uptake either by direct inhibition of folate transport into the intestinal mucosa or by inhibition of folate conjugase activity. To examine these possibilities, rats were gavaged chronically with PHT using either the sodium salt (NaPHT) or the free acid (HPHT) in the presence of folk… Expand
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