Phenytoin: neuroprotection or neurotoxicity?

@article{Hesselink2017PhenytoinNO,
  title={Phenytoin: neuroprotection or neurotoxicity?},
  author={Jan M Keppel Hesselink and David J Kopsky},
  journal={Neurological Sciences},
  year={2017},
  volume={38},
  pages={1137-1141}
}
Phenytoin is an 80-year young molecule and new indications are still emerging. The neuroprotective potential of phenytoin has been evaluated for decades. Recently, a positive phase II trial supported its further development in the treatment of optic neuritis in multiple sclerosis. In 1942, however, peripheral neuritis was first reported to be an adverse event of phenytoin, and since then a small but steady stream of publications discussed peripheral polyneuropathy as being a possible adverse… CONTINUE READING
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