Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke

  title={Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke},
  author={B. W. Yoon and H.-J. Bae and K. S. Hong and S. M. Lee and B. J. Park and K. H. Yu and M-K Han and Y. S. Lee and Dong Kyoon Chung and J. M. Park and S-W Jeong and B. C. Lee and K.‐H. Cho and J. S. Kim and S. H. Lee and Kang Mok Yoo},
  pages={146 - 149}
In this study, we sought to elucidate whether phenylpropanolamine (PPA) in cold remedies (small and divided doses) increases the risk of hemorrhagic stroke (HS). PPA exposure significantly increased the risk, and the risk was much higher in women. In women, linear trends were also found in recency, duration, and dosage of PPA exposure. PPA contained in cold remedies increases the risk of HS, particularly in women. 

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PPA exposure significantly increased the risk of hemorrhagic stroke, and the risk was much higher in women, and linear trends were also found in recency, duration, and dosage of PPA exposure.

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Phenylpropanolamine and the risk of hemorrhagic stroke.

It is suggested that phenylpropanolamine in appetite suppressants, and possibly in cough and cold remedies, is an independent risk factor for hemorrhagic stroke in women.

Intracranial hemorrhages due to phenylpropanolamine.

2 patients with intracranial hemorrhage after ingestion of diet pills containing phenylpropanolamine (PPA) in combination with caffeine are described, suggesting the mechanism may be induction of a transient hypertensive crisis.

Intracerebral hemorrhage and phenylpropanolamine use

Direct questioning of use of this medication in cases of unexplained intracranial hemorrhage in previously healthy young individuals may reveal an unsuspected high frequency of this association.

Racial differences in the incidence of intracerebral hemorrhage

Compared with whites, African Americans have a twofold increased risk for intracerebral hemorrhage, most of this risk may be explained by differences in educational attainment and systolic blood pressure.

Cerebrovascular Risk Factors and Stroke Subtypes: Differences Between Ethnic Groups

Physiological cerebrovascular risk factors for the UK black population are similar to those of the US black population, but behavioral risk factors differ, and future measures for secondary prevention should take this into consideration.

Adverse drug reaction highlights of

  • Inpharma
  • 2000

Adverse drug reaction highlights

  • Inpharma
  • 2000