Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the kappa 2B (enkephalin-sensitive) binding site.

@article{Rothman1993PhenylpiperidineOA,
  title={Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the kappa 2B (enkephalin-sensitive) binding site.},
  author={Richard B. Rothman and Heng Li Xu and George U. Char and Ahrrum Kim and B R de Costa and Kenner C. Rice and Dennis M. Zimmerman},
  journal={Peptides},
  year={1993},
  volume={14 1},
  pages={17-20}
}
Certain opioid antagonists of the phenylpiperidine series (PPAs), such as LY255582, seem uniquely efficacious at producing weight loss in lean and meal-fed obese Zucker rats. Comparison of the pharmacological and receptor binding profile of PPAs that promote marked weight loss with those that do not has failed to find any obvious differences between these two groups of narcotic antagonists, which might explain the differences in their biological activities. The potent stimulatory effect of… CONTINUE READING