Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats.

@article{Cheung2012PhenylpiperazineDW,
  title={Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats.},
  author={Timothy H. C. Cheung and Brian C Nolan and Lindsey R Hammerslag and Suzanne M. Weber and John P Durbin and Natalie A. Peartree and Robert H. Mach and Robert R. Luedtke and Janet L. Neisewander},
  journal={Neuropharmacology},
  year={2012},
  volume={63 8},
  pages={1346-59}
}
This study examined cocaine self-administration after pretreatments with three structurally related compounds that bind selectively to dopamine D3 receptors (D3Rs) relative to the D2 receptor subtype (D2Rs) and exhibit varying intrinsic activities in the forskolin-stimulated adenylyl cyclase assay. The compounds are: a) WC10, a D3R weak partial agonist/antagonist with 42-fold D3R:D2R selectivity, b) WC26, a 51-fold selective D3R partial agonist, c) WC44, a 23-fold selective D3R agonist. Rats… CONTINUE READING