Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults

@article{Moretto2006PhenylmethanesulfonylFE,
  title={Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults},
  author={Angelo Moretto and M. Bertolazzi and E Capodicasa and Maja Peraica and Rudy J. Richardson and Maria Luisa Scapellato and Marcello Lotti},
  journal={Archives of Toxicology},
  year={2006},
  volume={66},
  pages={67-72}
}
It has been recently reported that phenyl-methanesulfonyl fluoride (PMSF) when given to hens after a neuropathic organophosphate (OP) promotes organophosphate-induced delayed polyneuropathy (OPIDP). Chicks are resistant to OPIDP despite high inhibition/aging of neuropathy target esterase (NTE), the putative target of OPIDP initiation. However, when PMSF (300 mg/kg s.c.) is given to chicks after di-butyl 2,2-dichlorovinyl phosphate (DBDCVP, 1 or 5 mg/kg s.c.), OPIDP is promoted. Inhibition/aging… 
Phenylmethylsulfonyl fluoride, a potentiator of neuropathy, alters the interaction of organophosphorus compounds with soluble brain esterases.
TLDR
Kinetic data of esterase inhibition were obtained for PMSF with a soluble chicken brain fraction and analyzed using a kinetic model with a multienzymatic system in which inhibition occurred with the simultaneous chemical hydrolysis of the inhibitor and ongoing inhibition (inhibition during the substrate reaction).
Organophosphate polyneuropathy and neuropathy target esterase: Studies with methamidophos and its resolved optical isomers
TLDR
It is concluded that when racemic methamidophos is given to hens, initiation and protection from OPIDP is due to the interaction of d-(+) methamodophos with NTE, and both isomers are likely to be due to interactions with another unknown target.
Triphenylphosphite neuropathy in hens
TLDR
TPP neuropathy in the hen is likely to be the same as typical OPIDP, and the unusual effects of combined treatment to hens with TPP and PMSF are explained by the prolonged pharmacokinetics of TPP and by the dual effect of PMSF i.e. protection from and promotion of OPIDs.
Mechanisms of Prediction and Potential Causation of Organophosphate Induced Delayed Neurotoxicity.
TLDR
The hypothesis that FAP compounds inhibit serine esterases by scission of the P—C bond, in agreement with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, is supported.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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