Phenylketonuria and juvenile idiopathic arthritis: a case report

@article{Zhu2021PhenylketonuriaAJ,
  title={Phenylketonuria and juvenile idiopathic arthritis: a case report},
  author={Ting Ting Zhu and Jin Wu and L. Wang and X. Sun},
  journal={BMC Pediatrics},
  year={2021},
  volume={21}
}
Background Phenylketonuria (PKU) is a genetic metabolic disorder in which patients have no ability to convert phenylalanine to tyrosine. Several autoimmune diseases have been reported to combine with PKU, co-existent of PKU and Juvenile Idiopathic Arthritis (JIA) has not been presented. Case presentation The girl was diagnosed with PKU at the age of 1 month confirmed by molecular data. At the age of 3.5 years, she presented with pain and swelling of her right ankle, right knee, and right hip… Expand

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References

SHOWING 1-9 OF 9 REFERENCES
The challenges of managing coexistent disorders with phenylketonuria: 30 cases.
TLDR
Investigation for co-existent disorders when the clinical history is not completely consistent with phenylketonuria is essential and Integrating care of a second condition with PKU management is challenging. Expand
Phenylketonuria
TLDR
Tetrahydrobiopterin stimulates phenylalanine hydroxylase activity in about 20% of patients, and in those patients serves as a useful adjunct to the phenylketonuria-restricted diet because it increases phenylAlanine tolerance and allows some dietary freedom. Expand
Metabolism of glycosaminoglycans in the course of juvenile idiopathic arthritis.
TLDR
The plausible role of factors related to catabolism and synthesis of PGs/GAGs as well as the contribution of immunological processes to shaping the changes of extracellular matrix components in the course of JIA are described. Expand
Pathogenic implications of age of onset in juvenile rheumatoid arthritis.
TLDR
An analysis of age of onset in juvenile rheumatoid arthritis was performed and it is possible that JRA is not a homogenous disease, or that there are age-sex related differences in host susceptibility or pathogenic agents. Expand
Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression
TLDR
Data from this study support the hypothesis that inflammation in JIA patients enhances the enzymatic activity of both IDO and GTP-CH1 but decreases the efficacy of the co-factor BH4. Expand
Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms
TLDR
Findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons. Expand
Role in neuropsychiatric symptoms
  • Biol Psychiatry. 2011;70: 175–82. Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Zhu et al. BMC Pediatrics
  • 2021
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