Phenylketonuria: phenylalanine inhibits brain pyruvate kinase in vivo.

@article{Miller1973PhenylketonuriaPI,
  title={Phenylketonuria: phenylalanine inhibits brain pyruvate kinase in vivo.},
  author={Alexander Luke Miller and Richard R. Hawkins and Richard L. Veech},
  journal={Science},
  year={1973},
  volume={179 4076},
  pages={904-6}
}
The hypothesis that brain damage in phenylketonuria is related to inhibition of pyruvate kinase by phenylalanine was examined in rat brain in vivo. One hour after a single injection of phenylalanine into the rat, the brains were removed and completely frozen in less than a second. The concentration of phenylalanine in the brain was comparable to that found… CONTINUE READING