Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation

@inproceedings{Mancini2018PhenylindanesIB,
  title={Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation},
  author={Ross S. Mancini and Yanfei Wang and Donald F. Weaver},
  booktitle={Front. Neurosci.},
  year={2018}
}
Coffee consumption has been correlated with a decreased risk of developing Alzheimer's disease (AD) and Parkinson's disease (PD), but the mechanism by which coffee may provide neuroprotection in humans is not fully understood. We hypothesized that compounds found in brewed coffee may elicit neuroprotective effects by inhibiting the aggregation of amyloid-beta (Aβ) and tau (AD) or α-synuclein (PD). Three instant coffee extracts (light roast, dark roast, decaffeinated dark roast) and six coffee… CONTINUE READING

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