Phenylglyoxal is not a selective inhibitor of phagocytosis.

  title={Phenylglyoxal is not a selective inhibitor of phagocytosis.},
  author={M L van Schaik and Ron S. Weening and Dirk Roos},
  journal={Journal of cell science},
In 1976, it has been reported that phenylglyoxal (C6H5COCHO) selectively inhibits endocytosis in phagocytes of rabbit and mouse. We have tested the specificity of this compound by measuring its effect on human neutrophil chemotaxis, respiration and release of lysosomal enzymes. Pretreatment of human neutrophils with 100 microgram phenylglyoxal/ml for 30 min at 37 degrees C resulted in almost complete inhibition of phagocytosis of opsonized zymosan. However, after treatment with phenylglyoxal… CONTINUE READING